circRNAs对哺乳动物胎盘养分转运和胎儿发育的影响

doi:10.11843/j.issn.0366-6964.2019.10.001

Abstract

Abstract: circRNAs are a subclass of endogenous non-coding RNAs with a closed continuous loop. In recent years, lots of studies have found that circRNAs are ubiquitous in eukaryotes. They not only have certain conserved characteristics and cell specificity, but also play a regulatory role in gene transcription. Regulation of nutrient transport across the placenta is very important for the fetal development, which even determines whether the fetus could be successfully delivered and also affects its future growth and development. Studies in pigs and mice have shown that circRNAs play an important regulatory role in placental nutrient transport and fetal development. This paper reviews the sources, production mechanisms, classification, characteristics and functions of circRNAs. Combined with animal production, the regulation role of circRNAs on nutrient transport of glucose, amino acids and fatty acids in mammalian placenta and fetal development are also reviewed.

CLC Number:

S811.4

HE Tianle, DONG Guozhong, YANG Zhenguo. Regulation of circRNAs on Mammalian Placental Nutrient Transport and Fetal Development[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2019, 50(10): 1955-1962.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: https://www.xmsyxb.com/EN/10.11843/j.issn.0366-6964.2019.10.001

https://www.xmsyxb.com/EN/Y2019/V50/I10/1955

References 67

[1]	WESTHOLM J O,MIURA P,OLSON S,et al.Genome-wide analysis of Drosophila circular RNAs reveals their structural and sequence properties and age-dependent neural accumulation[J].Cell Rep,2014,9(5):1966-1980.
[2]	WILUSZ J E,SHARP P A.A circuitous route to noncoding RNA[J].Science,2013,340(6131):440-441.
[3]	VENØ M T,HANSEN T B,VENØ S T,et al.Spatio-temporal regulation of circular RNA expression during porcine embryonic brain development[J].Genome Biol,2015,16:245.
[4]	DANG Y J,YANG L Y,HU B Q,et al.Tracing the expression of circular RNAs in human pre-implantation embryos[J].Genome Biol,2016,17:130.
[5]	YANG Z G,AWAN F M,DU W W,et al.The circular RNA interacts with STAT3,increasing its nuclear translocation and wound repair by modulating Dnmt3a and miR-17 function[J].Mol Ther,2017,25(9):2062-2074.
[6]	杨震国.能量水平对猪胎盘和胎儿生长发育的影响及circ-Amotl1表达调控机制[D].成都:四川农业大学,2017.
	YANG Z G.Effects of dietary energy levels on placental and fetal development in gilts and the mechanism investigation of circ-Amotl1 expression[D].Chengdu:Sichuan Agricultural University,2017.(in Chinese)
[7]	LIANG G M,YANG Y L,NIU G L,et al.Genome-wide profiling of Sus scrofa circular RNAs across nine organs and three developmental stages[J].DNA Res,2017,24(5):523-535.
[8]	RAN M L,WENG B,CHEN B,et al.Strand-specific RNA sequencing in pig testes identifies developmentally regulated genes and circular RNAs[J].Genes Genom,2017,39(10):1083-1094.
[9]	ZHANG X O,WANG H B,ZHANG Y,et al.Complementary sequence-mediated exon circularization[J].Cell,2014,159(1):134-147.
[10]	ZENG Y,DU W W,WU Y Y,et al.A circular RNA binds to and activates AKT phosphorylation and nuclear localization reducing apoptosis and enhancing cardiac repair[J].Theranostics,2017,7(16):3842-3855.
[11]	JECK W R,SORRENTINO J A,WANG K,et al.Circular RNAs are abundant,conserved,and associated with ALU repeats[J].RNA,2013,19(2):141-157.
[12]	MEMCZAK S,JENS M,ELEFSINIOTI A,et al.Circular RNAs are a large class of animal RNAs with regulatory potency[J].Nature,2013,495(7441):333-338.
[13]	SALZMAN J,GAWAD C,WANG P L,et al.Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types[J].PLoS One,2012,7(2):e30733.
[14]	DANAN M,SCHWARTZ S,EDELHEIT S,et al.Transcriptome-wide discovery of circular RNAs in Archaea[J].Nucleic Acids Res,2012,40(7):3131-3142.
[15]	ZHANG Y,ZHANG X O,CHEN T,et al.Circular intronic long noncoding RNAs[J].Mol Cell,2013,51(6):792-806.
[16]	WANG F L,NAZARALI A J,JI S P.Circular RNAs as potential biomarkers for cancer diagnosis and therapy[J].Am J Cancer Res,2016,6(6):1167-1176.
[17]	COCQUERELLE C,MASCREZ B,HÉTUIN D,et al.Mis-splicing yields circular RNA molecules[J].FASEB J,1993,7(1):155-160.
[18]	SUZUKI H,ZUO Y H,WANG J H,et al.Characterization of RNase R-digested cellular RNA source that consists of lariat and circular RNAs from pre-mRNA splicing[J].Nucleic Acids Res,2006,34(8):e63.
[19]	SUZUKI H,TSUKAHARA T.A view of pre-mRNA splicing from RNase R resistant RNAs[J].Int J Mol Sci,2014,15(6):9331-9342.
[20]	HANSEN T B,JENSEN T I,CLAUSEN B H,et al.Natural RNA circles function as efficient microRNA sponges[J].Nature,2013,495(7441):384-388.
[21]	LI G X,HUANG M,CAI Y Q,et al.Circ-U2AF1 promotes human glioma via derepressing neuro-oncological ventral antigen 2 by sponging hsa-miR-7-5p[J].J Cell Physiol,2019,234(6):9144-9155.
[22]	ZHENG Q P,BAO C Y,GUO W J,et al.Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs[J].Nat Commun,2016,7:11215.
[23]	HAN D,LI J X,WANG H M,et al.Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression[J].Hepatology,2017,66(4):1151-1164.
[24]	HALL I F,CLIMENT M,QUINTAVALLE M,et al.Circ_Lrp6,a circular RNA enriched in vascular smooth muscle cells,acts as a sponge regulating miRNA-145 function[J].Circ Res,2019,124(4):498-510.
[25]	WANG K,LONG B,LIU F,et al.A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223[J].Eur Heart J,2016,37(33):2602-2611.
[26]	ASHWAL-FLUSS R,MEYER M,PAMUDURTI N R,et al.circRNA biogenesis competes with pre-mRNA splicing[J].Mol Cell,2014,56(1):55-66.
[27]	WANG Y,WANG Z F.Efficient backsplicing produces translatable circular mRNAs[J].RNA,2015,21(2):172-179.
[28]	DU W W,YANG W N,LI X M,et al.A circular RNA circ-DNMT1 enhances breast cancer progression by activating autophagy[J].Oncogene,2018,37(44):5829-5842.
[29]	LI A,HUANG W L,ZHANG X X,et al.Identification and characterization of CircRNAs of two pig breeds as a new biomarker in metabolism-related diseases[J].Cell Physiol Biochem,2018,47(6):2458-2470.
[30]	CHEN B,HUANG S L.Circular RNA:an emerging non-coding RNA as a regulator and biomarker in cancer[J].Cancer Lett,2018,418:41-50.
[31]	JANSSON N,PETTERSSON J,HAAFIZ A,et al.Down-regulation of placental transport of amino acids precedes the development of intrauterine growth restriction in rats fed a low protein diet[J].J Physiol,2006,576(3):935-946.
[32]	JANSSON N,ROSARIO F J,GACCIOLI F,et al.Activation of placental mTOR signaling and amino acid transporters in obese women giving birth to large babies[J].J Clin Endocr Metab,2013,98(1):105-113.
[33]	吕佳琪,华雯妤,王恬.胚胎营养环境对动物出生后营养代谢的调控研究[J].动物营养学报,2016,28(2):335-344.
	LYU J Q,HUA W Y,WANG T.Effects of embryonic nutrition environment on the nutritional metabolism after birth[J].Chinese Journal of Animal Nutrition,2016,28(2):335-344.(in Chinese)
[34]	MARCONI A M,PAOLINI C,BUSCAGLIA M,et al.The impact of gestational age and fetal growth on the maternal-fetal glucose concentration difference[J].Obstet Gynecol,1996,87(6):937-942.
[35]	韩志强,宋兴超,王海军,等.哺乳动物妊娠中miRNA的作用[J].畜牧兽医学报,2018,49(11):2310-2316.
	HAN Z Q,SONG X C,WANG H J,et al.The function of miRNA in mammalian pregnancy[J].Acta Veterinaria et Zootechnica Sinica,2018,49(11):2310-2316.(in Chinese)
[36]	IOANNIDIS J,DONADEU F X.Circulating miRNA signatures of early pregnancy in cattle[J].BMC Genomics,2016,17:184.
[37]	ROSSANT J,CROSS J C.Placental development:lessons from mouse mutants[J].Nat Rev Genet,2001,2(7):538-548.
[38]	JOOST H G,THORENS B.The extended GLUT-family of sugar/polyol transport facilitators:nomenclature,sequence characteristics,and potential function of its novel members[J].Mol Membr Biol,2001,18(4):247-256.
[39]	HOGAN A,HEYNER S,CHARRON M J,et al.Glucose transporter gene expression in early mouse embryos[J].Development,1991,113(1):363-372.
[40]	ERICSSON A,HAMARK B,POWELL T L,et al.Glucose transporter isoform 4 is expressed in the syncytiotrophoblast of first trimester human placenta[J].Hum Reprod,2004,20(2):521-530.
[41]	MOUILLET J F,CHU T J,NELSON D M,et al.MiR-205 silences MED1 in hypoxic primary human trophoblasts[J].FASEB J,2010,24(6):2030-2039.
[42]	DONKER R B,MOUILLET J F,NELSON D M,et al.The expression of Argonaute2 and related microRNA biogenesis proteins in normal and hypoxic trophoblasts[J].Mol Hum Reprod,2007,13(4):273-279.
[43]	CHAN S Y,LOSCALZO J.MicroRNA-210:a unique and pleiotropic hypoxamir[J].Cell Cycle,2010,9(6):1072-1083.
[44]	KENIRY A,OXLEY D,MONNIER P,et al.The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r[J].Nat Cell Biol,2012,14(7):659-665.
[45]	FORBES K,WESTWOOD M,BAKER P N,et al.Insulin-like growth factor I and Ⅱ regulate the life cycle of trophoblast in the developing human placenta[J].Am J Physiol Cell Physiol,2008,294(6):C1313-C1322.
[46]	ESTEVES J V,ENGUITA F J,MACHADO U F.microRNAs-mediated regulation of skeletal muscle GLUT4 expression and translocation in insulin resistance[J].J Diabetes Res,2017,2017:7267910.
[47]	RONG D W,SUN H D,LI Z X,et al.An emerging function of circRNA-miRNAs-mRNA axis in human diseases[J].Oncotarget,2017,8(42):73271-73281.
[48]	KOS A,DIJKEMA R,ARNBERG A C,et al.The hepatitis delta (δ) virus possesses a circular RNA[J].Nature,1986,323(6088):558-560.
[49]	YANG Y,FAN X J,MAO M W,et al.Extensive translation of circular RNAs driven by N6-methyladenosine[J].Cell Res,2017,27(5):626-641.
[50]	PAMUDURTI N R,BARTOK O,JENS M,et al.Translation of circRNAs[J].Mol Cell,2017,66(1):9-21.
[51]	YANG Y B,GAO X Y,ZHANG M L,et al.Novel role of FBXW7 circular RNA in repressing glioma tumorigenesis[J].J Natl Cancer Inst,2018,110(3):304-315.
[52]	CHO I S,KIM J,SEO H Y,et al.Cloning and characterization of microRNAs from porcine skeletal muscle and adipose tissue[J].Mol Biol Rep,2010,37(7):3567-3574.
[53]	GUO J M,MIAO Y,XIAO B X,et al.Differential expression of microRNA species in human gastric cancer versus non-tumorous tissues[J].J Gastroenterol Hepatol,2009,24(4):652-657.
[54]	JIN W W,DODSON M V,MOORE S S,et al.Characterization of microRNA expression in bovine adipose tissues:a potential regulatory mechanism of subcutaneous adipose tissue development[J].BMC Mol Biol,2010,11:29.
[55]	GERIN I,BOMMER G,MCCOIN C S,et al.Roles for miRNA-378/378* in adipocyte gene expression and lipogenesis[J].Am J Physiol Endocrinol Metab,2010,299(2):E198-E206.
[56]	NAKANISHI N,NAKAGAWA Y,TOKUSHIGE N,et al.The up-regulation of microRNA-335 is associated with lipid metabolism in liver and white adipose tissue of genetically obese mice[J].Biochem Biophys Res Commun,2009,385(4):492-496.
[57]	FATICA A,BOZZONI I.Long non-coding RNAs:new players in cell differentiation and development[J].Nat Rev Genet,2014,15(1):7-21.
[58]	LEGNINI L,DI TIMOTEO G,ROSSI F,et al.Circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis[J].Mol Cell,2017,66(1):22-37,e9.
[59]	GAO W L,LIU M,YANG Y Y,et al.The imprinted H19 gene regulates human placental trophoblast cell proliferation via encoding miR-675 that targets Nodal Modulator 1(NOMO1)[J].RNA Biol,2012,9(7):1002-1010.
[60]	YANG Q C,WU J,ZHAO J,et al.Circular RNA expression profiles during the differentiation of mouse neural stem cells[J].BMC Syst Biol,2018,12(8):128-140.
[61]	RYBAK-WOLF A,STOTTMEISTER C,GLA?AR P,et al.Circular RNAs in the mammalian brain are highly abundant,conserved,and dynamically expressed[J].Mol Cell,2015,58(5):870-885.
[62]	SZABO L,MOREY R,PALPANT N J,et al.Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development[J].Genome Biol,2015,16:126.
[63]	YOU X T,VLATKOVIC I,BABIC A,et al.Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity[J].Nat Neurosci,2015,18(4):603-610.
[64]	FAN X Y,ZHANG X N,WU X L,et al.Single-cell RNA-seq transcriptome analysis of linear and circular RNAs in mouse preimplantation embryos[J].Genome Biol,2015,16:148.
[65]	XU T Y,WU J,HAN P,et al.Circular RNA expression profiles and features in human tissues:a study using RNA-seq data[J].BMC Genomics,2017,18(Suppl 6):680.
[66]	HU X P,AO J P,LI X Y,et al.Competing endogenous RNA expression profiling in pre-eclampsia identifies hsa_circ_0036877 as a potential novel blood biomarker for early pre-eclampsia[J].Clin Epigenetics,2018,10:48.
[67]	QIAN Y T,LU Y Q,RUI C,et al.Potential significance of circular RNA in human placental tissue for patients with preeclampsia[J].Cell Physiol Biochem,2016,39(4):1380-1390.

Regulation of circRNAs on Mammalian Placental Nutrient Transport and Fetal Development

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References 67

Related Articles 1

Recommended Articles

Metrics

Comments